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Amelia continues to care Betty and Leo with Owen, but she breaks up with him when his anger on Betty's lying about her identity reveals his true feelings about addicts.

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He develops a project to heal burn wounds with fish skin and asks Maggie to move in with him. His relationship with Maggie continues to develop and he leans on her throughout his mother's tough recovery process. Eventually, he finds that he is happiest working miracles in the OR.

Jackson is saved from near-accident which sets off a spiritual quest for him.

During the birth of his daughter, he professes his love for Teddy, finally allowing himself to have happiness in his life without fear of screwing it up.

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He prepares for his daughter's birth and goes to therapy, where he learns he self-sabotages happiness before life can destroy it for him and how to stop that cycle. Owen legally adopts Leo and continues life as a single father. His hurtful comments cause Amelia to end things. However, their renewed happiness is short-lived when Betty reveals she has been lying about her identity the whole, causing Owen to lash out. The family is thrown for a loop when Teddy returns and reveals her pregnancy, but Owen decides to be with Amelia.

Owen continues to care for Leo and Betty with Amelia.

Richard stands by Catherine through her recovery and her acceptance of the fact that she has to live with cancer. She undergoes surgery but the tumor can't be removed entirely. His bad spell is ended when Catherine is diagnosed with a chondrosarcoma on her spine. While still abstaining from alcohol, he becomes a dry drunk displaying erratic and at times aggressive behavior.

Richard goes down a dark path after the death of his sponsor.

Over time, it starts itching that she has given up her job, causing some friction with Alex. It deeply upsets him, but the two reconcile when she discovers her mental illness has been plaguing her due to imbalanced medications. After stepping down as Chief appears insufficient, she asks Ben for a break from their marriage.

Bailey continues her quest to eliminate stress from her life.

Later, he has to stand by as Jo slips into a depression after finding out the circumstances of her conception and birth and refuses to talk to him. His mother visits for a while and she gently nudges her son and Jo towards having kids. While initially struggling, he rises to the occasion and sometimes butts heads with Bailey.

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Newlywed Alex faces a professional challenge when Bailey appoints him as her interim Chief of Surgery.

She also starts working on a new research project about ingestible non-invasive diagnostic devices. After dates with both, she chooses for Andrew and lets the relationship slowly develop. Cece sets up a string of dates, but eventually Meredith finds herself wooed by Andrew DeLuca and new ortho Chief Atticus Lincoln.

After finding herself desiring love and passion, Meredith turns to matchmaker Cece Colvin to find her the perfect match.

And the drama continues as a windstorm blows through Seattle, causing the power to go out at Grey Sloan, leaving the doctors scrambling to save their patients' lives, including Meredith, who desperately needs to get to her patient for her heart transplant. Romance is brewing in ways you did not see coming as doctor Teddy Altman is back in an explosive love triangle.